|
KMID : 0043320230460060500
|
|
Archives of Pharmacal Research
2023 Volume.46 No. 6 p.500 ~ p.534
|
|
|
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
|
|
Seok Jin-Kyung
Kim Min-hyuk
Kang Han-Chang
Cho Yong?Yeon
Lee Hye-Suk
Lee Joo-Young
|
|
|
Abstract
|
|
|
|
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.
|
|
|
KEYWORD
|
|
|
cGAS, STING, DNA, immunity, Infammation, Cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|